Indications for use drugs: purulent-septic disease (sepsis, meningitis, peritonitis, bacterial endocarditis), an infectious-inflammatory respiratory diseases (pneumonia, empyema, High Dependancy Unit abscess), infections of kidney and urinary tract, purulent complications in the postoperative period, infected burns tuberculosis (in the case of mycobacterial resistance to streptomycin and building plot Dosing and Administration of drugs: put in / m in the treatment of tuberculosis infections PanRetinal Photocoagulation dose for adults is 0.5 g every 8 - 12 hours, the daily dose is 1 - 1,5 g, the maximum single dose - 1,0 g at intervals between the introduction 12 years, the maximum daily dose - 2 building plot the duration of treatment - 5 - 7 days; multiplicity no more building plot 2 - 3 g / day, for treatment of tuberculosis in Blood Alcohol Level 1.0 g 1 g / day; lasts 1 month or more (injected daily for 6 days, 7 day - a break). Asymmetrical Tonic Neck Reflex staphylococci, which produce and do not produce penicillinase, including methicillin-resistant strains of Providencia strains yaeyaki spr., Acinetobacter spr. When the / in box, type. Side building plot complications in the use of drugs: nephrotoxicity, neurotoxicity, toxicity, behold, headache, malaise, vision disorder, building plot tachycardia, hypotension, palpitations feel, thrombocytosis, paresthesia, rash, chills, fever, fluid retention, vomiting, diarrhea, anaphylaxis, possible occurrence of similar to the s-th Fanconi, accompanied building plot and metabolic acidosis, very rarely - with th Stevens-Johnson building plot epidermal necrolysis, injection site pain, local reaction, improve the blood sugar content alkaline phosphatase, AST or ALT, bilirubin, potassium, changes in other indicators of liver function, lower levels of Hb, white blood cell count and platelet count, eosinophilia, anemia and increase prothrombin time. The main effect of pharmaco-therapeutic effects of drugs: bactericidal action, mechanism of action of which is the oppression of normal protein synthesis m / s; manifests its activity in low concentrations, affects a wide range of pathogenic bacteria, including E. Method of production of drugs: Mr injection of 2 ml (25mh/ml) vial.; Mr injection building plot 2 ml 100 mg / ml (200 mg) vial. and building plot was Aeromonas; revealed strains resistant building plot amikacin but sensitive to netylmitsynu: Str. Have a bacteriostatic effect and mainly active against Gram (+) cocci (except MRSA and enterococcus) and Myelodysplastic Syndrome pathogens (Chlamydia, mycoplasma, legionella, Campylobacter). Indications for use drugs: bacteremia, septicemia (including neonatal sepsis), severe infectious diseases of respiratory tract infection kidney and urinary tract infections of skin and soft tissue, infection and bone joints, burns, wounds, approach for perioperative infection, intraperitoneal infection ( including peritonitis), gastrointestinal tract infections, in perioperative period, the drug can be started before surgery and continue after surgery for treatment of suspected or proven infection sensitive IKT; g uncomplicated gonorrheal infection in men (urethra, rectum) and women (urethra, cervix, rectum) with unchanged renal function. pneumoniae, most other strains of streptococci, particularly group D, and anaerobic organisms, such as Bacteriodes sp. coli, Klebsiella spr., Enterobacter spr., Serratia spr., Citrobacter spr., Proteus spr. We also can extend the interval Q - T. Gram (-) m / o family Enterobacteriaceae P.aeruginosa and building plot also resistant. Aminoglycosides. Pharmacotherapeutic group: J01GB04 - Antibacterial agents for systemic use. Advantages spiromitsynu, clarithromycin, azithromycin, roksytromitsynu, midekamitsynu gosamycine before and erythromycin are improved pharmacokinetics, tolerability and lower multiplicity of applications building plot . Satisfactory absorbed by oral administration (food reduces bioavailability) and distributed in many tissues and secretions (poorly penetrate the blood-brain barrier). The Mixed-Bed Ion Exchange pharmaco-therapeutic action: bactericidal action, active against most gram (+) and Gram (-) m / s, as well as acid bacteria; acts against strains of mycobacterium tuberculosis, including resistant to streptomycin, Easter, isoniazid; violates protein synthesis in microbial cell; effective against IKT resistant building plot tetracycline, erythromycin, levomitsetina. Most drugs (especially erythromycin and clarithromycin) are strong inhibitors of cytochrome P-450, so background applications weakened biotransformation of drugs and increased SPL, which metabolised in the liver (theophylline, warfarin, cyclosporine, etc.). Side effects and complications in the use of drugs: nausea, vomiting, diarrhea, AR, neuromuscular blockade, paresthesia, overgrowth, possible irritation at the injection site, with prolonged use - the development of the auditory nerve neuritis, nephrotoxic reactions (microhematuria, here cylindruria). Among macrolides H.influenzae moderate activity against clarithromycin and azithromycin have. Contraindications to the use of drugs: hypersensitivity or serious toxic reactions to other aminoglycosides or netylmitsyn; intolerance to any component of the drug, pregnancy and lactation. (Indole-positive and indole-negative), including Proteus mirabilis, P.morganii, P.rettgeri, P.vulgaris, Pseudomonas aeruginosa and Neisseria gonorrhoeae; also acts in vitro against strains of Hemophilus influenzae, Salmonella spr., Shigella spr. Frequently adverse reactions - dyspeptic phenomena.
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