The main effect of pharmaco-therapeutic effects of drugs: has antiemetic effect with vomiting of various origins (except psychogenic vomiting and vestibular origin) and the serotonin blocker dopaminovyh receptors, chemoreceptors inhibits brain weakens sensitivity of visceral nerves that transmit impulses from the pylorus and duodenum to emetics center, through the hypothalamus and parasympathetic nervous system regulates and coordinates the motor activity of the upper gastrointestinal tract, increases gastric tone and intestine, accelerates gastric emptying, reduces hastrostaz, prevents and ezofahealnomu pyloric reflux stimulates intestinal peristalsis; normalizes the selection of bile, reduces spasm of sphincter Oddi, does not change his tone, removes dyskinesia Gallbladder; no m-holinoblokuyuchoyi, anhyhistaminnoyi, antyserotoninovoyi ganglioplegic and action; not affect the tone blood vessels in the brain, blood funky respiratory function, as well as kidney and liver to blood and secretion of gastric and pancreatic gland, stimulates the secretion of prolactin. Side effects and complications in the use of drugs: Not observed. Method of production of drugs: Table. Side effects and complications in the use of drugs: extrapyramidal disorder, passage smooth muscle spasm disorders, skin itching, rash, hives, increase in plasma prolactin, very rarely - galactorrhoea, gynecomastia. Contraindications to the use of drugs: hypersensitivity to the drug, gastrointestinal bleeding, intestinal obstruction, gastrointestinal tract perforation, pigment and prolaktonozalezhni tumors, phaeochromocytoma, epilepsy, glaucoma, extrapyramidal disorders, and trimester of pregnancy, lactation and children under 2 years. of 0,01 g; Table. Indications for use drugs: nausea, vomiting, dyspeptic symptoms complex, resulting from slowing emptying stomach, Ventilation/perfusion Scan esophagitis (feeling full stomach, bloating and epigastric pain, belching, flatulence, heartburn); nausea and vomiting, functional or organic origin (including funky diet disorders, treatment or radiation here nausea and vomiting caused by antagonists of dopamine (levodopa and bromokryptyn). chewing on 80 mg, 125 mg. Pharmacotherapeutic group: A0ZFA-agents used in functional disorders funky the alimentary canal. Indications medicine: nausea and vomiting of various origins (due to anesthesia, radiation and chemotherapy, toxemia, migraine, CCT violation diet), gastrointestinal tract dysmotility Fasting Blood Sugar functional dyspepsia, reflux esophagitis, duodenitis peptic ulcer, diabetic hastroparezi, postoperative gastric atony; used to facilitate sensing or Studies of radio-opaque alimentary canal. radiological study of adults before entering into / in to 10 - 20 mg per 5 - 15 min to study, patients with clinically manifest hepatic-renal insufficiency initially prescribed dose in less than two times normal, the next dose depends on individual patient response to Helicobacter pylori infection, oral adults appoint 10 mg 3 g / day, if necessary, dose can be increased, the duration of treatment depends on the severity and course of disease violation of peristalsis of the upper gastrointestinal tract, nausea, vomiting, and desires to vomiting, diabetic hastroparez: 10 mg Metoclopramide 1-3 times a day, children 2 to 14 years - the recommended dose of 0.1 mg, the maximum daily dose is 0,5 mg Metoclopramide / kg of body weight, examination funky the upper gastrointestinal tract: Metoclopramide 10-20 mg as a slow (1-2 min) i / v injection for 10 min before the test, children from 2 to 14 years -0.1 mg Metoclopramide / kg body weight in a slow (1-2 min) / v injection for 10 min here the test.
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